Increased prefrontal volume in PD with levodopa‐induced dyskinesias: A voxel‐based morphometry study
Identifieur interne : 001617 ( Main/Exploration ); précédent : 001616; suivant : 001618Increased prefrontal volume in PD with levodopa‐induced dyskinesias: A voxel‐based morphometry study
Auteurs : Antonio Cerasa [Italie] ; Demetrio Messina [Italie] ; Pierfrancesco Pugliese [Italie] ; Maurizio Morelli [Italie] ; Pierluigi Lanza [Italie] ; Maria Salsone [Italie] ; Fabiana Novellino [Italie] ; Giuseppe Nicoletti [Italie] ; Gennarina Arabia [Italie] ; Aldo Quattrone [Italie]Source :
- Movement Disorders [ 0885-3185 ] ; 2011-04.
Descripteurs français
- Pascal (Inist)
English descriptors
- KwdEn :
- Aged, Antiparkinson Agents (adverse effects), Brain Mapping, Dyskinesia, Dyskinesia, Drug-Induced (etiology), Dyskinesia, Drug-Induced (pathology), Female, Humans, Imaging, Three-Dimensional, Levodopa, Levodopa (adverse effects), Magnetic Resonance Imaging (methods), Male, Middle Aged, Morphometry, Nervous system diseases, Nuclear magnetic resonance imaging, Parkinson Disease (drug therapy), Parkinson Disease (pathology), Parkinson disease, Parkinson's disease, Prefrontal Cortex (drug effects), Prefrontal Cortex (pathology), Statistics, Nonparametric, Voxel, early onset of disease, levodopa‐induced dyskinesias, magnetic resonance imaging, voxel‐based morphometry.
- MESH :
- chemical , adverse effects : Antiparkinson Agents, Levodopa.
- drug effects : Prefrontal Cortex.
- drug therapy : Parkinson Disease.
- etiology : Dyskinesia, Drug-Induced.
- methods : Magnetic Resonance Imaging.
- pathology : Dyskinesia, Drug-Induced, Parkinson Disease, Prefrontal Cortex.
- Aged, Brain Mapping, Female, Humans, Imaging, Three-Dimensional, Male, Middle Aged, Statistics, Nonparametric.
Abstract
Levodopa‐induced dyskinesias represent disabling complications from long‐term therapy with dopaminergic drugs for treating Parkinson's disease (PD). Although several neuroimaging studies have reported altered striatofrontal function that contributes to the emergence of these motor complications, the neuroanatomical correlates of this disorder are still unknown. Optimized voxel‐based morphometry (VBM) was applied to the MRI brain images of 36 PD patients with levodopa‐induced dyskinesias, 36 PD patients without levodopa‐induced dyskinesias, and 32 age‐ and sex‐matched controls. The VBM analysis comparing dyskinetic and nondyskinetic groups provided evidence of increased gray matter volume of the bilateral inferior frontal gyrus in dyskinetic patients, a finding that was more evident in patients with early‐onset PD. No significant differences were detected in the dyskinetic and nondyskinetic groups when compared with the controls. Our findings suggest that the presence of dyskinesias in patients with PD is characterized by an aberrant neural plasticity that could play a role in the pathophysiology of these motor complications. © 2011 Movement Disorder Society
Url:
DOI: 10.1002/mds.23660
Affiliations:
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Catanzaro</wicri:noRegion></affiliation></author><author><name sortKey="Quattrone, Aldo" sort="Quattrone, Aldo" uniqKey="Quattrone A" first="Aldo" last="Quattrone">Aldo Quattrone</name><affiliation wicri:level="1"><country xml:lang="fr">Italie</country><wicri:regionArea>Neuroimaging Research Unit, Institute of Neurological Sciences, National Research Council, Germaneto (CZ)</wicri:regionArea><wicri:noRegion>Germaneto (CZ)</wicri:noRegion></affiliation><affiliation wicri:level="1"><country xml:lang="fr">Italie</country><wicri:regionArea>Institute of Neurology, University “Magna Græcia,” Catanzaro</wicri:regionArea><wicri:noRegion>” Catanzaro</wicri:noRegion></affiliation></author></analytic><monogr></monogr><series><title level="j">Movement Disorders</title><title level="j" type="abbrev">Mov. Disord.</title><idno type="ISSN">0885-3185</idno><idno type="eISSN">1531-8257</idno><imprint><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><pubPlace>Hoboken</pubPlace><date type="published" when="2011-04">2011-04</date><biblScope unit="vol">26</biblScope><biblScope unit="issue">5</biblScope><biblScope unit="page" from="807">807</biblScope><biblScope unit="page" to="812">812</biblScope></imprint><idno type="ISSN">0885-3185</idno></series><idno type="istex">4F918549885C721053AABC7C046D5049639F42CF</idno><idno type="DOI">10.1002/mds.23660</idno><idno type="ArticleID">MDS23660</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0885-3185</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Aged</term><term>Antiparkinson Agents (adverse effects)</term><term>Brain Mapping</term><term>Dyskinesia</term><term>Dyskinesia, Drug-Induced (etiology)</term><term>Dyskinesia, Drug-Induced (pathology)</term><term>Female</term><term>Humans</term><term>Imaging, Three-Dimensional</term><term>Levodopa</term><term>Levodopa (adverse effects)</term><term>Magnetic Resonance Imaging (methods)</term><term>Male</term><term>Middle Aged</term><term>Morphometry</term><term>Nervous system diseases</term><term>Nuclear magnetic resonance imaging</term><term>Parkinson Disease (drug therapy)</term><term>Parkinson Disease (pathology)</term><term>Parkinson disease</term><term>Parkinson's disease</term><term>Prefrontal Cortex (drug effects)</term><term>Prefrontal Cortex (pathology)</term><term>Statistics, Nonparametric</term><term>Voxel</term><term>early onset of disease</term><term>levodopa‐induced dyskinesias</term><term>magnetic resonance imaging</term><term>voxel‐based morphometry</term></keywords><keywords scheme="MESH" type="chemical" qualifier="adverse effects" xml:lang="en"><term>Antiparkinson Agents</term><term>Levodopa</term></keywords><keywords scheme="MESH" qualifier="drug effects" xml:lang="en"><term>Prefrontal Cortex</term></keywords><keywords scheme="MESH" qualifier="drug therapy" xml:lang="en"><term>Parkinson Disease</term></keywords><keywords scheme="MESH" qualifier="etiology" xml:lang="en"><term>Dyskinesia, Drug-Induced</term></keywords><keywords scheme="MESH" qualifier="methods" xml:lang="en"><term>Magnetic Resonance Imaging</term></keywords><keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Dyskinesia, Drug-Induced</term><term>Parkinson Disease</term><term>Prefrontal Cortex</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Aged</term><term>Brain Mapping</term><term>Female</term><term>Humans</term><term>Imaging, Three-Dimensional</term><term>Male</term><term>Middle Aged</term><term>Statistics, Nonparametric</term></keywords><keywords scheme="Pascal" xml:lang="fr"><term>Dyskinésie</term><term>Imagerie RMN</term><term>Lévodopa</term><term>Maladie de Parkinson</term><term>Morphométrie</term><term>Pathologie du système nerveux</term><term>Voxel</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Levodopa‐induced dyskinesias represent disabling complications from long‐term therapy with dopaminergic drugs for treating Parkinson's disease (PD). Although several neuroimaging studies have reported altered striatofrontal function that contributes to the emergence of these motor complications, the neuroanatomical correlates of this disorder are still unknown. Optimized voxel‐based morphometry (VBM) was applied to the MRI brain images of 36 PD patients with levodopa‐induced dyskinesias, 36 PD patients without levodopa‐induced dyskinesias, and 32 age‐ and sex‐matched controls. The VBM analysis comparing dyskinetic and nondyskinetic groups provided evidence of increased gray matter volume of the bilateral inferior frontal gyrus in dyskinetic patients, a finding that was more evident in patients with early‐onset PD. No significant differences were detected in the dyskinetic and nondyskinetic groups when compared with the controls. Our findings suggest that the presence of dyskinesias in patients with PD is characterized by an aberrant neural plasticity that could play a role in the pathophysiology of these motor complications. © 2011 Movement Disorder Society</div></front></TEI><affiliations><list><country><li>Italie</li></country></list><tree><country name="Italie"><noRegion><name sortKey="Cerasa, Antonio" sort="Cerasa, Antonio" uniqKey="Cerasa A" first="Antonio" last="Cerasa">Antonio Cerasa</name></noRegion><name sortKey="Arabia, Gennarina" sort="Arabia, Gennarina" uniqKey="Arabia G" first="Gennarina" last="Arabia">Gennarina Arabia</name><name sortKey="Lanza, Pierluigi" sort="Lanza, Pierluigi" uniqKey="Lanza P" first="Pierluigi" last="Lanza">Pierluigi Lanza</name><name sortKey="Messina, Demetrio" sort="Messina, Demetrio" uniqKey="Messina D" first="Demetrio" last="Messina">Demetrio Messina</name><name sortKey="Morelli, Maurizio" sort="Morelli, Maurizio" uniqKey="Morelli M" first="Maurizio" last="Morelli">Maurizio Morelli</name><name sortKey="Nicoletti, Giuseppe" sort="Nicoletti, Giuseppe" uniqKey="Nicoletti G" first="Giuseppe" last="Nicoletti">Giuseppe Nicoletti</name><name sortKey="Novellino, Fabiana" sort="Novellino, Fabiana" uniqKey="Novellino F" first="Fabiana" last="Novellino">Fabiana Novellino</name><name sortKey="Pugliese, Pierfrancesco" sort="Pugliese, Pierfrancesco" uniqKey="Pugliese P" first="Pierfrancesco" last="Pugliese">Pierfrancesco Pugliese</name><name sortKey="Quattrone, Aldo" sort="Quattrone, Aldo" uniqKey="Quattrone A" first="Aldo" last="Quattrone">Aldo Quattrone</name><name sortKey="Quattrone, Aldo" sort="Quattrone, Aldo" uniqKey="Quattrone A" first="Aldo" last="Quattrone">Aldo Quattrone</name><name sortKey="Salsone, Maria" sort="Salsone, Maria" uniqKey="Salsone M" first="Maria" last="Salsone">Maria Salsone</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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